Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases.

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第一作者： Yuko,Kato

第一单位： Toray Industries, Inc., Pharmaceutical Research Laboratories, 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan; Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan. Electronic address: Yuko_Kato@nts.toray.co.jp.

作者： Yuko,Kato ^[1] ; Nobuhiro,Fuchi ^[2] ; Yutaka,Nishimura ^[2] ; Ayano,Watanabe ^[2] ; Mai,Yagi ^[2] ; Yasuhito,Nakadera ^[2] ; Eriko,Higashi ^[2] ; Masateru,Yamada ^[2] ; Takumi,Aoki ^[2] ; Hideo,Kigoshi ^[3]

作者单位： Toray Industries, Inc., Pharmaceutical Research Laboratories, 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan; Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan. Electronic address: Yuko_Kato@nts.toray.co.jp. ^[1] Toray Industries, Inc., Pharmaceutical Research Laboratories, 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan. ^[2] Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan. ^[3]

关键词 Anti-GBM glomerulonephritis rat model Chronic kidney diseases Spirocyclic diamine Urea sEH inhibitor