换一批Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis.
第一作者：
Lisa,Leung
第一单位：
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada ; Ontario Cancer Institute/Princess Margaret Hospital, and University Health Network, University of Toronto, Toronto, Ontario, Canada.
作者：
医学主题词
动物(Animals);癌, 胰腺管(Carcinoma, Pancreatic Ductal);细胞系, 肿瘤(Cell Line, Tumor);细胞转化, 肿瘤(Cell Transformation, Neoplastic);上皮细胞(Epithelial Cells);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因敲低技术(Gene Knockdown Techniques);基因沉默(Gene Silencing);人类(Humans);小鼠(Mice);肿瘤侵润(Neoplasm Invasiveness);肿瘤转移(Neoplasm Metastasis);胰腺管(Pancreatic Ducts);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras));RNA, 小分子干扰(RNA, Small Interfering);信号传导(Signal Transduction);Smad4蛋白质(Smad4 Protein);存活率分析(Survival Analysis);转化生长因子β(Transforming Growth Factor beta);ras蛋白质类(ras Proteins)
DOI
10.1371/journal.pone.0084366
PMID
24386371
发布时间
2021-10-21
- 浏览9
PloS one
e84366页
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