Mendelian randomization in health research: using appropriate genetic variants and avoiding biased estimates.

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第一作者： Amy E,Taylor

第一单位： MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK. Electronic address: amy.taylor@bristol.ac.uk.

作者： Amy E,Taylor ^[1] ; Neil M,Davies ^[2] ; Jennifer J,Ware ^[3] ; Tyler,VanderWeele ^[4] ; George Davey,Smith ^[2] ; Marcus R,Munafò ^[5]

作者单位： MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK. Electronic address: amy.taylor@bristol.ac.uk. ^[1] MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK. ^[2] MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK; MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK. ^[3] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA. ^[4] MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK. ^[5]

关键词 Causal inference Instrumental variable Mendelian randomization Smoking Tobacco

主题词因果律(Causality);全基因组关联研究(Genome-Wide Association Study);人类(Humans);孟德尔随机化分析(Mendelian Randomization Analysis);研究设计(Research Design);吸烟(Smoking)

DOI 10.1016/j.ehb.2013.12.002

PMID 24388127

发布时间 2023-11-04

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