Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition.

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第一作者： Yuzuru,Taguchi

第一单位： Department of Comparative Biology & Experimental Medicine; Faculty of Veterinary Medicine; University of Calgary; Calgary, AB Canada.

作者： Yuzuru,Taguchi ^[1] ; Hermann M,Schätzl ^[2]

作者单位： Department of Comparative Biology & Experimental Medicine; Faculty of Veterinary Medicine; University of Calgary; Calgary, AB Canada. ^[1] Department of Comparative Biology & Experimental Medicine; Faculty of Veterinary Medicine; University of Calgary; Calgary, AB Canada; Departments of Molecular Biology and of Veterinary Sciences; University of Wyoming; Laramie, Wyoming, USA. ^[2]

关键词 PrPC-PrPSc interaction dominant-negative inhibition epicenter of structural changes interaction interface prion conversion

主题词氨基酸序列(Amino Acid Sequence);动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);小鼠(Mice);分子序列数据(Molecular Sequence Data);PrPC蛋白质类(PrPC Proteins);PrPSc蛋白质类(PrPSc Proteins);朊病毒病(Prion Diseases);蛋白质构象(Protein Conformation);蛋白质相互作用域和基序(Protein Interaction Domains and Motifs);蛋白质相互作用图谱(Protein Interaction Mapping);序列缺失(Sequence Deletion)

DOI 10.4161/pri.27500

PMID 24401595

发布时间 2021-10-21

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Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition.

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Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition.

Prion

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Prion

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