Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of hedgehog signaling pathway.

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作者： Minhang,Xin ^[1] ; Jun,Wen ^[2] ; Feng,Tang ^[2] ; Chongxing,Tu ^[2] ; Wei,Huang ^[2] ; Han,Shen ^[2] ; Xinge,Zhao ^[2] ; Lingfei,Cheng ^[2] ; Mengyu,Wang ^[2] ; Liandi,Zhang ^[2]

作者单位： Department of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi'an Jiaotong University, No. 76, Yanta West Road, Xi'an 710061, P.R. China; Jiangsu Simcere Pharmaceutical Co. Ltd., Jiangsu Key Laboratory of Molecular Targeted Antitumor Drug Research, No 699-18, Xuan Wu District, Nanjing 210042, P.R. China. Electronic address: xmhcpu@163.com. ^[1] Jiangsu Simcere Pharmaceutical Co. Ltd., Jiangsu Key Laboratory of Molecular Targeted Antitumor Drug Research, No 699-18, Xuan Wu District, Nanjing 210042, P.R. China. ^[2]

关键词 Hedgehog signaling pathway Inhibitors Pharmacokinetic properties SAR

主题词苯甲酰胺类(Benzamides);猬蛋白质类(Hedgehog Proteins);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);嘧啶类(Pyrimidines);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2013.12.050

PMID 24405704

发布时间 2014-01-27

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