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首页> Toxicon : official journal of the International Society on Toxinology> Enzyme specificity and effects of gyroxin, a serine protease from the venom of the South American rattlesnake Crotalus durissus terrificus, on protease-activated receptors.

Enzyme specificity and effects of gyroxin, a serine protease from the venom of the South American rattlesnake Crotalus durissus terrificus, on protease-activated receptors.

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作者： Camila M,Yonamine ^[1] ; Marcia Y,Kondo ^[2] ; Marcela B,Nering ^[3] ; Iuri E,Gouvêa ^[2] ; Débora,Okamoto ^[2] ; Douglas,Andrade ^[2] ; José Alberto A,da Silva ^[4] ; Alvaro R B,Prieto da Silva ^[5] ; Tetsuo,Yamane ^[6] ; Maria A,Juliano ^[2] ; Luiz,Juliano ^[2] ; Antônio J,Lapa ^[7] ; Mirian A F,Hayashi ^[3] ; Maria Teresa R,Lima-Landman ^[3]

作者单位： Depto Farmacologia, UNIFESP, São Paulo, SP, Brazil. Electronic address: camilamy@gmail.com. ^[1] Depto de Biofísica, UNIFESP, São Paulo, SP, Brazil. ^[2] Depto Farmacologia, UNIFESP, São Paulo, SP, Brazil. ^[3] Centro de Biotecnologia-IPEN, São Paulo, SP, Brazil. ^[4] Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil. ^[5] Universidade do Estado do Amazonas, Escola Superior de Ciências da Saúde - INCT, Manaus, Amazonas, Brazil. ^[6] Depto Farmacologia, UNIFESP, São Paulo, SP, Brazil; Universidade do Estado do Amazonas, Escola Superior de Ciências da Saúde - INCT, Manaus, Amazonas, Brazil. ^[7]

关键词 Astrocytes Barrel rotation syndrome Gyroxin Protease-activated receptors Serine protease Snake toxin

主题词动物(Animals);星形细胞(Astrocytes);钙(Calcium);促凝药(Coagulants);响尾蛇毒液类(Crotalid Venoms);响尾蛇属(Crotalus);胞质溶胶(Cytosol);水解作用(Hydrolysis);男(雄)性(Male);小鼠(Mice);受体, 蛋白酶激活(Receptors, Proteinase-Activated);丝氨酸蛋白酶类(Serine Proteases);信号传导(Signal Transduction);南美(South America);凝血酶(Thrombin);胰蛋白酶(Trypsin)

DOI 10.1016/j.toxicon.2013.12.002

PMID 24412460

发布时间 2014-02-10

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