Human CD19 and CD40L deficiencies impair antibody selection and differentially affect somatic hypermutation.

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作者： Menno C,van Zelm ^[1] ; Sophinus J W,Bartol ^[2] ; Gertjan J,Driessen ^[3] ; Françoise,Mascart ^[4] ; Ismail,Reisli ^[5] ; Jose L,Franco ^[6] ; Beata,Wolska-Kusnierz ^[7] ; Hirokazu,Kanegane ^[8] ; Louis,Boon ^[9] ; Jacques J M,van Dongen ^[2] ; Mirjam,van der Burg ^[2]

作者单位： Department of Immunology, Erasmus MC, Rotterdam, The Netherlands. Electronic address: m.vanzelm@erasmusmc.nl. ^[1] Department of Immunology, Erasmus MC, Rotterdam, The Netherlands. ^[2] Department of Immunology, Erasmus MC, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus MC, Rotterdam, The Netherlands. ^[3] Immunobiology Clinic, Hôpital Erasme, and Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles, Brussels, Belgium. ^[4] Meram Medical Faculty, Department of Pediatric Immunology and Allergy, Necmettin Erbakan University, Konya, Turkey. ^[5] Group of Primary Immunodeficiencies, University of Antioquia, Medellín, Colombia. ^[6] Department of Immunology, Children's Memorial Health Institute, Warsaw, Poland. ^[7] Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan. ^[8] Bioceros B.V., Utrecht, The Netherlands. ^[9]

关键词 CD19 CD40L autoreactivity immunoglobulin selection somatic hypermutation