One-year efficacy and safety results of secukinumab in patients with rheumatoid arthritis: phase II, dose-finding, double-blind, randomized, placebo-controlled study.

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第一作者： Mark C,Genovese

第一单位： From Stanford University, Palo Alto, California, USA; Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Cliniques Universitaires Saint-Luc, Brussels, Belgium; Novartis Pharma AG, Basel, Switzerland; NZOZ Centrum Medyczne Artur Racewicz, Bialystok, Poland; Medical Plus, Uherske Hradiste, Czech Republic; Arthritis Clinic, Jackson, Tennessee, USA; Konkuk University Medical Center, Seoul, South Korea; Health Research of Oklahoma, Oklahoma City, Oklahoma, USA; Centre for Inflammatory Joint Diseases, Munich, Germany; Kobe-Konan Yamate Clinic, Kobe, Japan; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.

作者： Mark C,Genovese ^[1] ; Patrick,Durez ; Hanno B,Richards ; Jerzy,Supronik ; Eva,Dokoupilova ; Jacob A,Aelion ; Sang-Heon,Lee ; Christine E,Codding ; Herbert,Kellner ; Takashi,Ikawa ; Sophie,Hugot ; Gregory,Ligozio ; Shephard,Mpofu

作者单位： From Stanford University, Palo Alto, California, USA; Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Cliniques Universitaires Saint-Luc, Brussels, Belgium; Novartis Pharma AG, Basel, Switzerland; NZOZ Centrum Medyczne Artur Racewicz, Bialystok, Poland; Medical Plus, Uherske Hradiste, Czech Republic; Arthritis Clinic, Jackson, Tennessee, USA; Konkuk University Medical Center, Seoul, South Korea; Health Research of Oklahoma, Oklahoma City, Oklahoma, USA; Centre for Inflammatory Joint Diseases, Munich, Germany; Kobe-Konan Yamate Clinic, Kobe, Japan; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA. ^[1]

关键词 AUTOIMMUNE DISEASES INTERLEUKINS METHOTREXATE MONOCLONAL ANTIBODIES RHEUMATOID ARTHRITIS SECUKINUMAB

主题词抗体, 单克隆(Antibodies, Monoclonal);抗风湿药(Antirheumatic Agents);关节炎, 类风湿(Arthritis, Rheumatoid);双盲法(Double-Blind Method);人类(Humans);注射, 皮下(Injections, Subcutaneous);治疗结果(Treatment Outcome)

DOI 10.3899/jrheum.130637

PMID 24429175

发布时间 2019-12-10

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