The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.

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作者： Colton,Linnertz ^[1] ; Lauren,Anderson ^[1] ; William,Gottschalk ^[2] ; Donna,Crenshaw ^[2] ; Michael W,Lutz ^[2] ; Jawara,Allen ^[3] ; Sunita,Saith ^[3] ; Mirta,Mihovilovic ^[1] ; James R,Burke ^[2] ; Kathleen A,Welsh-Bohmer ^[4] ; Allen D,Roses ^[5] ; Ornit,Chiba-Falek ^[6]

作者单位： Division of Neurology at the Department of Medicine, Duke University Medical Center, Durham, NC, USA. ^[1] Division of Neurology at the Department of Medicine, Duke University Medical Center, Durham, NC, USA; Division of Neurology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC, USA. ^[2] Institute for Genome Sciences & Policy, Duke University Medical Center, Durham, NC, USA. ^[3] Division of Neurology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC, USA. ^[4] Division of Neurology at the Department of Medicine, Duke University Medical Center, Durham, NC, USA; Division of Neurology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC, USA; Zinfandel Pharmaceuticals, Chapel Hill, NC, USA. ^[5] Division of Neurology at the Department of Medicine, Duke University Medical Center, Durham, NC, USA; Division of Neurology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC, USA; Institute for Genome Sciences & Policy, Duke University Medical Center, Durham, NC, USA. Electronic address: o.chibafalek@duke.edu. ^[6]

关键词 Alzheimer’s disease Apolipoprotein E Messenger RNA expression Poly-T polymorphism TOMM40 Transcription regulation