Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.
作者:
主题词
衰老(Aging);动物(Animals);动物, 新生(Animals, Newborn);胆管(Bile Ducts);细胞计数(Cell Count);细胞谱系(Cell Lineage);迷芽瘤(Choristoma);上皮细胞(Epithelial Cells);胎儿(Fetus);基因缺失(Gene Deletion);基因表达调控, 发育期(Gene Expression Regulation, Developmental);肝细胞核因子4(Hepatocyte Nuclear Factor 4);肝细胞(Hepatocytes);同源盒结构域蛋白质类(Homeodomain Proteins);肝(Liver);小鼠(Mice);SOX9转录因子类(SOX9 Transcription Factor);信号传导(Signal Transduction);干细胞(Stem Cells);转化生长因子β(Transforming Growth Factor beta);肿瘤抑制蛋白质类(Tumor Suppressor Proteins)
DOI
10.1242/dev.099481
PMID
24449835
发布时间
2021-10-21
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