Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.

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第一作者： Tonia,Aristotelous

第一单位： Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, United Kingdom.

作者： Tonia,Aristotelous ^[1] ; Seungkirl,Ahn ^[2] ; Arun K,Shukla ^[2] ; Sylwia,Gawron ^[1] ; Maria F,Sassano ^[3] ; Alem W,Kahsai ^[2] ; Laura M,Wingler ^[2] ; Xiao,Zhu ^[2] ; Prachi,Tripathi-Shukla ^[2] ; Xi-Ping,Huang ^[3] ; Jennifer,Riley ^[1] ; Jérémy,Besnard ^[1] ; Kevin D,Read ^[1] ; Bryan L,Roth ^[4] ; Ian H,Gilbert ^[1] ; Andrew L,Hopkins ^[1] ; Robert J,Lefkowitz ^[5] ; Iva,Navratilova ^[1]

作者单位： Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, United Kingdom. ^[1] Department of Medicine, Duke University Medical Center , Durham, North Carolina 27710, United States. ^[2] NIMH Psychoactive Drug Screening Program, Department of Pharmacology, The University of North Carolina Chapel Hill School of Medicine , Chapel Hill, North Carolina 27759, United States. ^[3] NIMH Psychoactive Drug Screening Program, Department of Pharmacology, The University of North Carolina Chapel Hill School of Medicine , Chapel Hill, North Carolina 27759, United States ; Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, The University of North Carolina Chapel Hill School of Medicine , Chapel Hill, North Carolina 27759, United States. ^[4] Department of Medicine, Duke University Medical Center , Durham, North Carolina 27710, United States ; Howard Hughes Medical Institute, Duke University Medical Center , Durham, North Carolina 27710, United States ; Department of Biochemistry, Duke University Medical Center , Durham, North Carolina 27710, United States. ^[5]

关键词 Fragment screening G-protein coupled receptors surface plasmon resonance β2 adrenoceptor

DOI 10.1021/ml400312j

PMID 24454993

发布时间 2022-01-29

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