Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer.

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第一作者： David C,Binder

第一单位： Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637 ; Department of Pathology, The University of Chicago, Chicago, IL 60637.

作者： David C,Binder ^[1] ; Boris,Engels ^[2] ; Ainhoa,Arina ^[2] ; Ping,Yu ^[3] ; James M,Slauch ^[4] ; Yang-Xin,Fu ^[2] ; Theodore,Karrison ^[5] ; Byron,Burnette ^[6] ; Christian,Idel ^[7] ; Ming,Zhao ^[8] ; Robert M,Hoffman ^[9] ; David H,Munn ^[10] ; Donald A,Rowley ^[11] ; Hans,Schreiber ^[12]

作者单位： Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637 ; Department of Pathology, The University of Chicago, Chicago, IL 60637. ^[1] Department of Pathology, The University of Chicago, Chicago, IL 60637 ; Committee on Immunology, The University of Chicago, Chicago, IL 60637. ^[2] Committee on Immunology, The University of Chicago, Chicago, IL 60637 ; Department of Medicine, The University of Chicago, Chicago, IL 60637. ^[3] Department of Microbiology and College of Medicine, University of Illinois, Urbana, IL 61801. ^[4] Department of Health Sciences, The University of Chicago, Chicago, IL 60637. ^[5] Department of Radiation Oncology, The University of Chicago, Chicago, IL 60637. ^[6] Department of Pathology, The University of Chicago, Chicago, IL 60637 ; Committee on Immunology, The University of Chicago, Chicago, IL 60637 ; Department of Otorhinolaryngology, University of Lübeck, Lübeck, Germany. ^[7] AntiCancer, Inc., San Diego, CA 92111. ^[8] AntiCancer, Inc., San Diego, CA 92111 ; Dept. of Surgery, University of California San Diego, San Diego, CA 92103-8220. ^[9] Georgia Health Sciences University Cancer Center, Augusta, GA 30912. ^[10] Department of Pathology, The University of Chicago, Chicago, IL 60637. ^[11] Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637 ; Department of Pathology, The University of Chicago, Chicago, IL 60637 ; Committee on Immunology, The University of Chicago, Chicago, IL 60637. ^[12]

关键词 CD8+ T cell rescue PD-L1 S. Typhimurium Tumor rejection vaccine

主题词动物(Animals);抗原呈递(Antigen Presentation);抗原, 肿瘤(Antigens, Neoplasm);细菌菌苗(Bacterial Vaccines);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);癌症疫苗(Cancer Vaccines);表位(Epitopes);女(雌)性(Female);淋巴细胞活化(Lymphocyte Activation);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);黑色素瘤, 实验性(Melanoma, Experimental);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);卵白蛋白(Ovalbumin);肽碎片(Peptide Fragments)

DOI 10.1158/2326-6066.CIR-13-0058

PMID 24455752

发布时间 2021-10-21

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Cancer immunology research

2013年1卷2期

123-33页

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Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer.

Cancer immunology research

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Cancer immunology research

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Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer.

Cancer immunology research

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Cancer immunology research

相关期刊

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