Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.
作者:
主题词
腺苷A3受体激动剂(Adenosine A3 Receptor Agonists);腺苷A3受体拮抗剂(Adenosine A3 Receptor Antagonists);动物(Animals);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);纤维化(Fibrosis);HEK293细胞(HEK293 Cells);人类(Humans);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);肾疾病(Kidney Diseases);分子构象(Molecular Conformation);核苷类(Nucleosides)
DOI
10.1021/jm4015313
PMID
24456490
发布时间
2021-10-21
- 浏览37

Journal of medicinal chemistry
1344-54页
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