Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice.-论文-万方医学网

作者： Su,Yang ^[1] ; Shanshan,Huang ^[2] ; Marta A,Gaertig ^[1] ; Xiao-Jiang,Li ^[3] ; Shihua,Li ^[4]

作者单位： Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Room 355, Atlanta, GA 30322, USA. ^[1] Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Room 355, Atlanta, GA 30322, USA; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. ^[2] Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Room 355, Atlanta, GA 30322, USA; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. Electronic address: xli2@emory.edu. ^[3] Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Room 355, Atlanta, GA 30322, USA. Electronic address: sli@emory.edu. ^[4]

主题词衰老(Aging);方差分析(Analysis of Variance);动物(Animals);细胞, 培养的(Cells, Cultured);DNA结合蛋白质类(DNA-Binding Proteins);疾病模型, 动物(Disease Models, Animal);雌激素拮抗剂(Estrogen Antagonists);基因表达调控(Gene Expression Regulation);HSC70热休克蛋白质类(HSC70 Heat-Shock Proteins);免疫沉淀法(Immunoprecipitation);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);突变(Mutation);神经变性(Nerve Degeneration);神经生长因子类(Nerve Growth Factors);肽类(Peptides);蛋白激酶C(Protein Kinase C);浦肯野细胞(Purkinje Cells);TATA盒结合蛋白质(TATA-Box Binding Protein);他莫昔芬(Tamoxifen);转录因子(Transcription Factors)

DOI 10.1016/j.neuron.2013.12.002

PMID 24462098

发布时间 2023-07-21

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Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice.

Neuron

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Neuron

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Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice.

Neuron

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Neuron

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