Anticancer potential of (pentamethylcyclopentadienyl)chloridoiridium(III) complexes bearing κP and κP,κS-coordinated Ph2 PCH2 CH2 CH2 S(O)x Ph (x=0-2) ligands.

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作者： Gerd,Ludwig ^[1] ; Ivan,Ranđelović ; Danijela,Maksimović-Ivanić ; Sanja,Mijatović ; Mirna Z,Bulatović ; Djordje,Miljković ; Marcus,Korb ; Heinrich,Lang ; Dirk,Steinborn ; Goran N,Kaluđerović

作者单位： Institute of Chemistry, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 2, 06120 Halle (Germany). ^[1]

关键词 apoptosis cytotoxic agents iridium(III) complexes metal-based drugs sulfur-functionalized phosphorus ligands

主题词抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);配位络合物(Coordination Complexes);结晶学, X线(Crystallography, X-Ray);人类(Humans);铱(Iridium);配体(Ligands);分子构象(Molecular Conformation);活性氧(Reactive Oxygen Species);构效关系(Structure-Activity Relationship)

DOI 10.1002/cmdc.201300479

PMID 24470190

发布时间 2014-07-03

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ChemMedChem

2014年9卷7期

1586-93页

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Anticancer potential of (pentamethylcyclopentadienyl)chloridoiridium(III) complexes bearing κP and κP,κS-coordinated Ph2 PCH2 CH2 CH2 S(O)x Ph (x=0-2) ligands.

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Anticancer potential of (pentamethylcyclopentadienyl)chloridoiridium(III) complexes bearing κP and κP,κS-coordinated Ph2 PCH2 CH2 CH2 S(O)x Ph (x=0-2) ligands.

ChemMedChem

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ChemMedChem

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