换一批
换一批Discovery of (E)-3-((styrylsulfonyl)methyl)pyridine and (E)-2-((styrylsulfonyl)methyl)pyridine derivatives as anticancer agents: synthesis, structure-activity relationships, and biological activities.
作者：
主题词
氨基吡啶类(Aminopyridines);动物(Animals);膜联蛋白A5(Annexin A5);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);曲线下面积(Area Under Curve);生物利用度(Biological Availability);细胞周期(Cell Cycle);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);结晶学, X线(Crystallography, X-Ray);药物设计(Drug Design);药物发现(Drug Discovery);甘氨酸(Glycine);半衰期(Half-Life);指示剂和试剂(Indicators and Reagents);Kaplan-Meiers评估(Kaplan-Meier Estimate);磁共振波谱学(Magnetic Resonance Spectroscopy);质谱分析法(Mass Spectrometry);小鼠(Mice);微粒体, 肝(Microsomes, Liver);模型, 分子(Models, Molecular);大鼠(Rats);构效关系(Structure-Activity Relationship);苯乙烯类(Styrenes);磺胺类(Sulfonamides);砜类(Sulfones);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1021/jm4019614
PMID
24471873
发布时间
2017-11-16
- 浏览31
Journal of medicinal chemistry
2275-91页
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