Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats.

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作者： Ting,Tai ^[1] ; Xin,Huang ^[2] ; Yuwen,Su ^[3] ; Jinzi,Ji ^[4] ; Yijing,Su ^[2] ; Zhenzhou,Jiang ^[5] ; Luyong,Zhang ^[6]

作者单位： Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China; Department of Central Laboratory, Nanjing First Hospital, Nanjing Medical University, 68 Chang Le Road, Nanjing 210006, China. ^[1] Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, 24 Tong Jia Xiang, Nanjing 210009, China. ^[2] Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China; School of Pharmacy, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China. ^[3] Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China; Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. ^[4] Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China; Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. Electronic address: beaglejiang@cpu.edu.cn. ^[5] Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, 24 Tong Jia Xiang, Nanjing 210009, China. Electronic address: lyzhang@cpu.edu.cn. ^[6]

关键词 CYP3A Glycyrrhizin Glycyrrhizin (PubChem CID: 14982)Ketoconazole (PubChem CID: 47576)Midazolam (PubChem CID: 4192)Pharmacokinetics Toxicity Triptolide Triptolide (PubChem CID: 107985)