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The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease.

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第一作者： Grant P,Parnell

第一单位： Institute for Immunology and Allergy Research, Westmead Millennium Institute University of Sydney, Sydney, New South Wales 2145, Australia.

作者： Grant P,Parnell ^[1] ; Prudence N,Gatt ^[1] ; Malgorzata,Krupa ^[2] ; Dorothee,Nickles ^[3] ; Fiona C,McKay ^[1] ; Stephen D,Schibeci ^[1] ; Marcel,Batten ^[4] ; Sergio,Baranzini ^[3] ; Andrew,Henderson ^[1] ; Michael,Barnett ^[5] ; Mark,Slee ^[2] ; Steve,Vucic ^[6] ; Graeme J,Stewart ^[1] ; David R,Booth ^[7]

作者单位： Institute for Immunology and Allergy Research, Westmead Millennium Institute University of Sydney, Sydney, New South Wales 2145, Australia. ^[1] School of Medicine, Flinders University of South Australia, South Australia 5042, Australia. ^[2] Department of Neurology, University of California at San Francisco, CA 94158, USA. ^[3] Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia. ^[4] Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050 Australia. ^[5] Westmead Clinical School, University of Sydney, Westmead Hospital, Sydney, New South Wales 2145, Australia. ^[6] Institute for Immunology and Allergy Research, Westmead Millennium Institute University of Sydney, Sydney, New South Wales 2145, Australia. Electronic address: david.booth@sydney.edu.au. ^[7]

关键词 EOMES Gene expression Multiple sclerosis TBX21 Transcription factors