A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition.

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第一作者： Toshihiko,Oki

第一单位： 1] Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan [2] Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

作者： Toshihiko,Oki ^[1] ; Koutarou,Nishimura ^[2] ; Jiro,Kitaura ^[2] ; Katsuhiro,Togami ^[2] ; Akie,Maehara ^[2] ; Kumi,Izawa ^[2] ; Asako,Sakaue-Sawano ^[3] ; Atsushi,Niida ^[4] ; Satoru,Miyano ^[5] ; Hiroyuki,Aburatani ^[6] ; Hiroshi,Kiyonari ^[7] ; Atsushi,Miyawaki ^[3] ; Toshio,Kitamura ^[1]

作者单位： 1] Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan [2] Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. ^[1] Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan. ^[2] 1] Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN [2] Life Function and Dynamics, ERATO, JST, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan. ^[3] Laboratory of DNA Information Analysis, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan. ^[4] 1] Laboratory of DNA Information Analysis, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan [2] Laboratory of Sequence Analysis, Human Genome Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai Minato-ku, Tokyo 108-8639, Japan. ^[5] Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. ^[6] Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, 2-2-3 Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan. ^[7]

主题词 3T3细胞(3T3 Cells);动物(Animals);凋亡调节蛋白质类(Apoptosis Regulatory Proteins);细菌蛋白质类(Bacterial Proteins);载体蛋白质类(Carrier Proteins);细胞系(Cell Line);周期素依赖激酶抑制剂p16(Cyclin-Dependent Kinase Inhibitor p16);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);周期素依赖激酶抑制剂p27(Cyclin-Dependent Kinase Inhibitor p27);周期素依赖激酶抑制剂p57(Cyclin-Dependent Kinase Inhibitor p57);G1期(G1 Phase);基因表达(Gene Expression);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);发光蛋白质类(Luminescent Proteins);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);微RNAs(MicroRNAs);RNA结合蛋白质类(RNA-Binding Proteins);重组融合蛋白质类(Recombinant Fusion Proteins);视网膜母细胞瘤蛋白质(Retinoblastoma Protein);硒结合蛋白质类(Selenium-Binding Proteins);干细胞(Stem Cells);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1038/srep04012

PMID 24500246

发布时间 2021-10-21

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A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition.

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A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition.

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