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首页> Gastroenterology> Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease.

Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease.

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作者： Theodore J,Sanders ^[1] ; Neil E,McCarthy ^[1] ; Edward M,Giles ^[1] ; Katherine L M,Davidson ^[1] ; Myriam L R,Haltalli ^[1] ; Sophie,Hazell ^[1] ; James O,Lindsay ^[2] ; Andrew J,Stagg ^[3]

作者单位： Centre for Immunology and Infectious Disease, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, England. ^[1] Digestive Diseases Clinical Academic Unit, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, England; The Royal London Hospital, Barts Health NHS Trust, London, England. ^[2] Centre for Immunology and Infectious Disease, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, England. Electronic address: a.stagg@qmul.ac.uk. ^[3]

关键词 Cytokine Immune Response Inflammatory Bowel Disease Regulation

主题词醛脱氢酶(Aldehyde Dehydrogenase);抗原, CD(Antigens, CD);病例对照研究(Case-Control Studies);细胞, 培养的(Cells, Cultured);结肠(Colon);Crohn病(Crohn Disease);树突细胞(Dendritic Cells);基因表达调控, 酶学(Gene Expression Regulation, Enzymologic);人类(Humans);回肠(Ileum);整合素α链(Integrin alpha Chains);肠黏膜(Intestinal Mucosa);巨噬细胞(Macrophages);表型(Phenotype);受体, 维甲酸(Receptors, Retinoic Acid);视黄醛脱氢酶(Retinal Dehydrogenase);信号传导(Signal Transduction);维甲酸(Tretinoin);增量调节(Up-Regulation)

DOI 10.1053/j.gastro.2014.01.057

PMID 24503130

发布时间 2020-12-09

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Gastroenterology

Gastroenterology

2014年146卷5期

1278-88.e1-2页

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2014年146卷5期

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