Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.

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作者： Yoon T,Jeon ^[1] ; Wu,Yang ^[2] ; Jennifer X,Qiao ^[3] ; Ling,Li ^[1] ; Rejean,Ruel ^[1] ; Carl,Thibeault ^[1] ; Sheldon,Hiebert ^[1] ; Tammy C,Wang ^[1] ; Yufeng,Wang ^[1] ; Yajun,Liu ^[1] ; Charles G,Clark ^[1] ; Henry S,Wong ^[1] ; Juliang,Zhu ^[1] ; Dauh-Rurng,Wu ^[1] ; Dawn,Sun ^[1] ; Bang-Chi,Chen ^[1] ; Arvind,Mathur ^[1] ; Silvi A,Chacko ^[4] ; Mary,Malley ^[4] ; Xue-Qing,Chen ^[4] ; Hong,Shen ^[4] ; Christine S,Huang ^[4] ; William A,Schumacher ^[5] ; Jeffrey S,Bostwick ^[5] ; Anne B,Stewart ^[5] ; Laura A,Price ^[5] ; Ji,Hua ^[5] ; Danshi,Li ^[4] ; Paul C,Levesque ^[4] ; Dietmar A,Seiffert ^[5] ; Robert,Rehfuss ^[5] ; Ruth R,Wexler ^[1] ; Patrick Y S,Lam ^[1]

作者单位： Discovery Chemistry, Bristol-Myers Squibb, 311 Pennington-Rocky Hill Road, Pennington, NJ 08534, USA. ^[1] Discovery Chemistry, Bristol-Myers Squibb, 311 Pennington-Rocky Hill Road, Pennington, NJ 08534, USA. Electronic address: wu.yang@bms.com. ^[2] Discovery Chemistry, Bristol-Myers Squibb, 311 Pennington-Rocky Hill Road, Pennington, NJ 08534, USA. Electronic address: jennifer.qiao@bms.com. ^[3] Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, 311 Pennington-Rocky Hill Road, Pennington, NJ 08534, USA. ^[4] Discovery Biology, Cardiovascular, Bristol-Myers Squibb, 311 Pennington-Rocky Hill Road, Pennington, NJ 08534, USA. ^[5]

关键词 Antiplatelet agent P2Y(1) antagonist Spiropiperidinylindolines