Indoleamine 2,3-dioxygenase 1 (IDO1) is up-regulated in thyroid carcinoma and drives the development of an immunosuppressant tumor microenvironment.
第一作者:
Sonia,Moretti
第一单位:
Departments of Internal Medicine (S.Moret., E.M., P.V., S.Morel., S.C., V.B., E.P.), Experimental Medicine and Biochemical Sciences (R.C., F.F., C.O., M.G.M., P.P.), Clinical and Experimental Medicine (A.A., R.G.), Chemistry and Drug Technology (A.M.), and Surgery (N.A.), University of Perugia, 06132 Perugia, Italy; Research Centre of Thyroid Proteomics and Genomics (S.Moret., E.M., P.V., S.Morel., N.A., E.P.), University of Perugia, 05100 Terni, Italy; Department of Clinical Sciences (M.S., S.F.), University of Rome "Sapienza," 00161 Rome, Italy; Department of Medicine (D.d.B., G.T.), Anatomic Pathology Unit, Bellaria Hospital, University of Bologna, 40139 Bologna, Italy; and Department of Molecular Medicine and Biotechnological Sciences (R.M.M., M.S.), University of Naples "Federico II," 80138 Naples, Italy.
作者:
医学主题词
腺癌, 滤泡性(Adenocarcinoma, Follicular);癌, 髓样(Carcinoma, Medullary);癌, 乳头状(Carcinoma, Papillary);细胞系, 肿瘤(Cell Line, Tumor);叉头转录因子类(Forkhead Transcription Factors);人类(Humans);吲哚胺-吡咯2,3-双加氧酶(Indoleamine-Pyrrole 2,3,-Dioxygenase);RNA, 信使(RNA, Messenger);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);甲状腺肿瘤(Thyroid Neoplasms);肿瘤微环境(Tumor Microenvironment);增量调节(Up-Regulation)
DOI
10.1210/jc.2013-3351
PMID
24517146
发布时间
2021-11-08
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