换一批
换一批Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.
作者：
主题词
抗肿瘤药(Antineoplastic Agents);结合部位(Binding Sites);硼酸化物(Boronic Acids);组织蛋白酶类(Cathepsins);细胞分裂(Cell Division);细胞系, 肿瘤(Cell Line, Tumor);结晶学, X线(Crystallography, X-Ray);药物设计(Drug Design);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);人类(Humans);胞间信号肽类和蛋白质类(Intercellular Signaling Peptides and Proteins);内酯类(Lactones);模型, 分子(Models, Molecular);分子构象(Molecular Conformation);肽类(Peptides);链霉菌属(Streptomyces);构效关系(Structure-Activity Relationship)
DOI
10.1021/jm500045x
PMID
24524217
发布时间
2019-12-10
- 浏览29
Journal of medicinal chemistry
2726-35页
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