Hypomethylation of the LH/choriogonadotropin receptor promoter region is a potential mechanism underlying susceptibility to polycystic ovary syndrome.
第一作者:
Peng,Wang
第一单位:
Center for Reproductive Medicine (P.W., H.Z., K.W., M.L., Y.B., H.L., Y.N., G.L., Z.-J.C.), Department of Gynecology (T.L.), and Department of Orthopedics (W.Z.), Provincial Hospital Affiliated to Shandong University, Jinan 250100, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics (P.W., H.Z., K.W., M.L., Y.B., H.L., Y.N., G.L., Z.-J.C.), Jinan 250021, China; The Key Laboratory for Reproductive Endocrinology of Ministry of Education (P.W., H.Z., K.W., M.L., Y.B., H.L., Y.N., G.L., Z.-J.C.), Jinan 250021, China; Shandong Provincial Key Laboratory of Reproductive Medicine (P.W., H.Z., K.W., M.L., Y.B., H.L., Y.N., G.L., Z.-J.C.), Jinan, China; and Department of Obstetrics and Gynecology (Z.-J.C.), Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
作者:
主题词
成年人(Adult);队列研究(Cohort Studies);CpG岛(CpG Islands);DNA甲基化(DNA Methylation);后成说, 遗传(Epigenesis, Genetic);女(雌)性(Female);疾病遗传易感性(Genetic Predisposition to Disease);粒层细胞(Granulosa Cells);人类(Humans);突变(Mutation);多囊卵巢综合征(Polycystic Ovary Syndrome);启动区, 遗传(Promoter Regions, Genetic);受体, LH(Receptors, LH);序列分析, DNA(Sequence Analysis, DNA);转录, 遗传(Transcription, Genetic)
DOI
10.1210/en.2013-1764
PMID
24527662
发布时间
2014-03-24
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Endocrinology
1445-52页
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