In vitro activity and in vivo animal model efficacy of IB-367 alone and in combination with imipenem and colistin against Gram-negative bacteria.

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作者： Oriana,Simonetti ^[1] ; Oscar,Cirioni ^[2] ; Roberto,Ghiselli ^[3] ; Fiorenza,Orlando ^[4] ; Carmela,Silvestri ^[2] ; Susanna,Mazzocato ^[2] ; Wojciech,Kamysz ^[5] ; Elzbieta,Kamysz ^[6] ; Mauro,Provinciali ^[4] ; Andrea,Giacometti ^[2] ; Mario,Guerrieri ^[3] ; Annamaria,Offidani ^[7]

作者单位： Clinic of Dermatology, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche - Ospedali Riuniti, Ancona, Italy. Electronic address: o.simonetti@univpm.it. ^[1] Clinic of Infectious Diseases, Department of Biomedical Sciences and Public Health, Università Politecnica delle Marche - Ospedali Riuniti, Ancona, Italy. ^[2] General Surgery and Surgery Methodology Clinic, Università Politecnica delle Marche - Ospedali Riuniti, Ancona, Italy. ^[3] Experimental Animal Models for Aging Units, Research Department, I.N.R.C.A. I.R.R.C.S., Ancona, Italy. ^[4] Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland. ^[5] Faculty of Chemistry, University of Gdansk, Gdansk, Poland. ^[6] Clinic of Dermatology, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche - Ospedali Riuniti, Ancona, Italy. ^[7]

关键词 Animal model Escherichia coli IB-367 Pseudomonas aeruginosa Wound infection