Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry.

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作者： Milon,Mondal ^[1] ; Nedyalka,Radeva ; Helene,Köster ; Ahyoung,Park ; Constantinos,Potamitis ; Maria,Zervou ; Gerhard,Klebe ; Anna K H,Hirsch

作者单位： Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG Groningen (The Netherlands) http://www.rug.nl/research/bio-organic-chemistry/hirsch/ ^[1]

关键词 STD NMR spectroscopy X-ray diffraction dynamic combinatorial chemistry enzyme inhibitors structure-based design

主题词天冬氨酸内肽酶类(Aspartic Acid Endopeptidases);组合化学技术(Combinatorial Chemistry Techniques);药物设计(Drug Design);磁共振波谱学(Magnetic Resonance Spectroscopy);模型, 分子(Models, Molecular);分子结构(Molecular Structure);构效关系(Structure-Activity Relationship);X线衍射(X-Ray Diffraction)

DOI 10.1002/anie.201309682

PMID 24532096

发布时间 2014-03-17

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Angewandte Chemie (International ed. in English)

2014年53卷12期

3259-63页

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Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry.

Angewandte Chemie (International ed. in English)

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Angewandte Chemie (International ed. in English)

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Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry.

Angewandte Chemie (International ed. in English)

相似文献

Angewandte Chemie (International ed. in English)

相关期刊

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