Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.

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作者： Xinpeng,Ma ^[1] ; Xiumei,Huang ; Gang,Huang ; Longshan,Li ; Yiguang,Wang ; Xiuquan,Luo ; David A,Boothman ; Jinming,Gao

作者单位： Departments of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX, 75390-8807, USA. ^[1]

关键词 cancer nanomedicine diester prodrug enzyme activation polymeric micelles β-lapachone

主题词细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);双香豆素(Dicumarol);酯类(Esters);冷冻干燥法(Freeze Drying);人类(Humans);微胶粒(Micelles);NAD(P)H脱氢酶(醌)(NAD(P)H Dehydrogenase (Quinone));萘醌类(Naphthoquinones);聚乙烯二醇类(Polyethylene Glycols);聚赖氨酸(Polylysine);药物前体(Prodrugs)

DOI 10.1002/adhm.201300590

PMID 24532286

发布时间 2024-03-21

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Advanced healthcare materials

2014年3卷8期

1210-6页

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Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.

Advanced healthcare materials

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Advanced healthcare materials

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Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.

Advanced healthcare materials

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Advanced healthcare materials

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