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Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

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作者: Jie,Huang [1] ; Jennifer E,Huffman ; Munekazu,Yamakuchi ; Stella,Trompet ; Folkert W,Asselbergs ; Maria,Sabater-Lleal ; David-Alexandre,Trégouët ; Wei-Min,Chen ; Nicholas L,Smith ; Marcus E,Kleber ; So-Youn,Shin ; Diane M,Becker ; Weihong,Tang ; Abbas,Dehghan ; Andrew D,Johnson ; Vinh,Truong ; Lasse,Folkersen ; Qiong,Yang ; Tiphaine,Oudot-Mellkah ; Brendan M,Buckley ; Jason H,Moore ; Frances M K,Williams ; Harry,Campbell ; Günther,Silbernagel ; Veronique,Vitart ; Igor,Rudan ; Geoffrey H,Tofler ; Gerjan J,Navis ; Anita,Destefano ; Alan F,Wright ; Ming-Huei,Chen ; Anton J M,de Craen ; Bradford B,Worrall ; Alicja R,Rudnicka ; Ann,Rumley ; Ebony B,Bookman ; Bruce M,Psaty ; Fang,Chen ; Keith L,Keene ; Oscar H,Franco ; Bernhard O,Böhm ; Andre G,Uitterlinden ; Angela M,Carter ; J Wouter,Jukema ; Naveed,Sattar ; Joshua C,Bis ; Mohammad A,Ikram ; Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) Consortium Neurology Working Group ; Michèle M,Sale ; Barbara,McKnight ; Myriam,Fornage ; Ian,Ford ; Kent,Taylor ; P Eline,Slagboom ; Wendy L,McArdle ; Fang-Chi,Hsu ; Anders,Franco-Cereceda ; Alison H,Goodall ; Lisa R,Yanek ; Karen L,Furie ; Mary,Cushman ; Albert,Hofman ; Jacqueline C M,Witteman ; Aaron R,Folsom ; Saonli,Basu ; Nena,Matijevic ; Wiek H,van Gilst ; James F,Wilson ; Rudi G J,Westendorp ; Sekar,Kathiresan ; Muredach P,Reilly ; CARDIoGRAM Consortium ; Russell P,Tracy ; Ozren,Polasek ; Bernhard R,Winkelmann ; Peter J,Grant ; Hans L,Hillege ; Francois,Cambien ; David J,Stott ; Gordon D,Lowe ; Timothy D,Spector ; James B,Meigs ; Winfried,Marz ; Per,Eriksson ; Lewis C,Becker ; Pierre-Emmanuel,Morange ; Nicole,Soranzo ; Scott M,Williams ; Caroline,Hayward ; Pim,van der Harst ; Anders,Hamsten ; Charles J,Lowenstein ; David P,Strachan ; Christopher J,O'Donnell ; CHARGE Consortium Hemostatic Factor Working Group
作者单位: From National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (J.H., A.D.J., C.J.O.); Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (J.H., A.D.J., C.J.O.); MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom (J.E.H., V.V., A.F.W., C.H.); The Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY (M.Y., C.J.L.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.d.C., R.G.J.W.), and Molecular Epidemiology (P.E.S.), Leiden University Medical Center, the Netherlands; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands (F.W.A.); Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands (F.W.A.); Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom (F.W.A.); Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine (M.S.-L., L.F., P.E., A.H.), Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden; INSERM UMRS 937, Pierre et Marie Curie University, Paris, France (D.-A.T., V.T., T.O.M., F.C.); ICAN Institute for Cardiometabolism and Nutrion, Paris, France (D.-A.T., V.T., F.C.); Departments of Public Health Sciences (W.M.C., B.B.W., F.C.) and Biochemistry and Molecular Genetics (M.M.S.), Center for Public Health Genomics, University of Virginia, Charlottesville, VA; Departments of Epidemiology (N.L.S., B.M.P., B.M.), Medicine (B.M.P., J.C.B.), and Health Services (B.M.P.), University of Washington, Seattle, WA; Group Health Research Institute, Group Health Cooperative, Seattle, WA (N.L.S., B.M.P.); Seattle Epidemiologic Research and Information Center, VA Office of Research and [1]
DOI 10.1161/ATVBAHA.113.302088
PMID 24578379
发布时间 2022-01-29
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Arteriosclerosis, thrombosis, and vascular biology

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