Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.-论文-万方医学网

作者： Travis K,Warren ^[1] ; Jay,Wells ^[1] ; Rekha G,Panchal ^[1] ; Kelly S,Stuthman ^[1] ; Nicole L,Garza ^[1] ; Sean A,Van Tongeren ^[1] ; Lian,Dong ^[1] ; Cary J,Retterer ^[1] ; Brett P,Eaton ^[1] ; Gianluca,Pegoraro ^[1] ; Shelley,Honnold ^[1] ; Shanta,Bantia ^[2] ; Pravin,Kotian ^[2] ; Xilin,Chen ^[2] ; Brian R,Taubenheim ^[3] ; Lisa S,Welch ^[1] ; Dena M,Minning ^[4] ; Yarlagadda S,Babu ^[2] ; William P,Sheridan ^[2] ; Sina,Bavari ^[1]

作者单位： Division of Molecular and Translational Sciences, Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Maryland 21702, USA. ^[1] BioCryst Pharmaceuticals Inc., Durham, North Carolina 27703, USA. ^[2] 1] BioCryst Pharmaceuticals Inc., Durham, North Carolina 27703, USA [2] Wilco Consulting, LLC, Durham, North Carolina 27712, USA. ^[3] MedExpert Consulting, Inc., Indialantic, Florida 32903, USA. ^[4]

主题词腺嘌呤(Adenine);腺苷(Adenosine);投药, 口服(Administration, Oral);动物(Animals);抗病毒药(Antiviral Agents);指导DNA的RNA聚合酶类(DNA-Directed RNA Polymerases);疾病模型, 动物(Disease Models, Animal);埃博拉病毒(Ebolavirus);纤丝病毒科(Filoviridae);纤丝病毒科感染(Filoviridae Infections);出血热, 埃博拉(Hemorrhagic Fever, Ebola);人类(Humans);注射, 肌肉内(Injections, Intramuscular);成束猴(Macaca fascicularis);马尔堡病毒病(Marburg Virus Disease);马尔堡病毒属(Marburgvirus);嘌呤核苷类(Purine Nucleosides);吡咯烷类(Pyrrolidines);RNA(RNA);时间因素(Time Factors)

DOI 10.1038/nature13027

PMID 24590073

发布时间 2022-03-11

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Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

Nature

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Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

Nature

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Nature

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