Inactivated influenza vaccine adjuvanted with bacterium-like particles induce systemic and mucosal influenza A virus specific T-cell and B-cell responses after nasal administration in a TLR2 dependent fashion.
作者:
主题词
佐剂, 免疫(Adjuvants, Immunologic);投药, 鼻内(Administration, Intranasal);动物(Animals);抗体, 病毒(Antibodies, Viral);B-淋巴细胞(B-Lymphocytes);女(雌)性(Female);免疫, 黏膜(Immunity, Mucosal);免疫球蛋白A, 分泌(Immunoglobulin A, Secretory);免疫球蛋白G(Immunoglobulin G);流感病毒A型, H1N1亚型(Influenza A Virus, H1N1 Subtype);流感病毒A型, H3N2亚型(Influenza A Virus, H3N2 Subtype);流感疫苗(Influenza Vaccines);乳乳球菌(Lactococcus lactis);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);正黏病毒科感染(Orthomyxoviridae Infections);Th1细胞(Th1 Cells);Toll样受体2(Toll-Like Receptor 2);疫苗, 灭活(Vaccines, Inactivated)
DOI
10.1016/j.vaccine.2014.02.019
PMID
24598720
发布时间
2014-05-05
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Vaccine
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