β-amyloid fibrils in Alzheimer disease are not inert when bound to copper ions but can degrade hydrogen peroxide and generate reactive oxygen species.
第一作者:
Jennifer,Mayes
第一单位:
Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, United Kingdom.
作者:
医学主题词
阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);铜(Copper);人类(Humans);过氧化氢(Hydrogen Peroxide);显微镜检查, 原子力(Microscopy, Atomic Force);肽碎片(Peptide Fragments);蛋白质结合(Protein Binding);活性氧(Reactive Oxygen Species)
DOI
10.1074/jbc.M113.525212
PMID
24619420
发布时间
2021-10-21
- 浏览22
The Journal of biological chemistry
12052-12062页
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