换一批Baicalein attenuates proteasome inhibition-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways.
第一作者：
Eun Byul,Jung
第一单位：
Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul 156-756, South Korea.
作者：
关键词
2′,7′-Dichlorofluorescin diacetate (Sigma-Aldrich Inc. CID 77718)3,3′-Dihexyloxacarbocyanine iodide (Sigma-Aldrich Inc. CID 9894321)3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (Sigma-Aldrich Inc. CID 3634887)Antibodies (Bid, Bax, Bcl-2, Bcl-xL, survivin, cytochrome c, PARP-1 and p53Apoptosis-related proteinsAssay kit for rat/mouse cytochrome c (R&D systems)Assay kits for caspases-8, -9 and -3 (R&D systems)BaicaleinBaicalein (EMD-Calbiochem Pubchem CID 5281605)Differentiated PC12 cellsMG115 (Sigma-Aldrich Inc. CID 9868928)MG132 (Sigma-Aldrich Inc. CID 462382)Proteasome inhibitionProtectionSanta Cruz Biotechnology, Inc)TiterTACS? colorimetric apoptosis detection kit (TrevigenInc.)
医学主题词
动物(Animals);细胞凋亡(Apoptosis);与BH3相互作用的凋亡激活蛋白质(BH3 Interacting Domain Death Agonist Protein);半胱氨酸天冬氨酸蛋白酶8(Caspase 8);细胞分化(Cell Differentiation);细胞系(Cell Line);细胞核(Cell Nucleus);黄烷酮类(Flavanones);谷胱甘肽(Glutathione);亮肽菌素类(Leupeptins);线粒体(Mitochondria);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);大鼠(Rats);活性氧(Reactive Oxygen Species)
DOI
10.1016/j.ejphar.2014.02.039
PMID
24631255
发布时间
2022-03-17
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