换一批
换一批Abuse liability assessment in preclinical drug development: predictivity of a translational approach for abuse liability testing using methylphenidate in four standardized preclinical study models.
第一作者：
Greet B A,Teuns
第一单位：
Discovery Sciences, Janssen Pharmaceutica NV, R&D, Turnhoutseweg 30, 2340 Beerse, Belgium. Electronic address: gteuns@its.jnj.com.
作者：
主题词
动物(Animals);中枢神经系统刺激剂(Central Nervous System Stimulants);右苯丙胺(Dextroamphetamine);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物评价, 临床前(Drug Evaluation, Preclinical);人类(Humans);男(雄)性(Male);哌醋甲酯(Methylphenidate);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);危险性评估(Risk Assessment);自我遵嘱服药(Self Administration);物质相关性障碍(Substance-Related Disorders)
DOI
10.1016/j.vascn.2014.02.002
PMID
24632211
发布时间
2014-12-09
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