首页> Analytical biochemistry> Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

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第一作者： Sarah,Walker

第一单位： Translational Drug Discovery Group, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK.

作者： Sarah,Walker ^[1] ; Cornelia,Meisenberg ^[2] ; Rachel A,Bibby ^[3] ; Trevor,Askwith ^[1] ; Gareth,Williams ^[1] ; Frauke H,Rininsland ^[4] ; Laurence H,Pearl ^[3] ; Antony W,Oliver ^[3] ; Sherif,El-Khamisy ^[5] ; Simon,Ward ^[6] ; John R,Atack ^[7]

作者单位： Translational Drug Discovery Group, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK. ^[1] Wellcome Trust DNA Repair Group, Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK. ^[2] Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, University of Sussex, Science Park Road, Brighton BN1 9RQ, UK. ^[3] Gyrasol Technologies, 2029 Becker Drive, Lawrence, KS 66047, USA. ^[4] Wellcome Trust DNA Repair Group, Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK; Mammalian Genome Stability Group, Kreb's Institute, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK. Electronic address: s.el-khamisy@sheffield.ac.uk. ^[5] Translational Drug Discovery Group, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK. Electronic address: Simon.Ward@sussex.ac.uk. ^[6] Translational Drug Discovery Group, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK. Electronic address: J.Atack@sussex.ac.uk. ^[7]

关键词 Assay Fragment High-throughput screen Inhibitor TDP1 Topoisomerase