Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia.

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作者： Brenton G,Mar ^[1] ; Lars B,Bullinger ^[2] ; Kathleen M,McLean ^[3] ; Peter V,Grauman ^[4] ; Marian H,Harris ^[5] ; Kristen,Stevenson ^[6] ; Donna S,Neuberg ^[6] ; Amit U,Sinha ^[7] ; Stephen E,Sallan ^[1] ; Lewis B,Silverman ^[1] ; Andrew L,Kung ^[8] ; Luca,Lo Nigro ^[9] ; Benjamin L,Ebert ^[4] ; Scott A,Armstrong ^[7]

作者单位： 1] Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts 02115, USA. ^[1] Department of Internal Medicine III, University of Ulm, Ulm 89081, Germany. ^[2] Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA. ^[3] Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. ^[4] Department of Pathology, Boston Children's Hospital, Boston, Massachusetts 02115, USA. ^[5] Biostatistics & Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA. ^[6] Human Oncology and Pathogenesis Program and Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ^[7] Department of Pediatrics, Columbia University Medical Center, New York, New York 10032, USA. ^[8] Oncoematologia Pediatrica, Azienda Policlinico OVE, 95125, Catania, Italy. ^[9]

主题词碱基序列(Base Sequence);DNA引物(DNA Primers);后成说, 遗传(Epigenesis, Genetic);外显子(Exons);组蛋白赖氨酸N-甲基转移酶(Histone-Lysine N-Methyltransferase);人类(Humans);分子序列数据(Molecular Sequence Data);突变(Mutation);前体细胞淋巴母细胞白血病淋巴瘤(Precursor Cell Lymphoblastic Leukemia-Lymphoma);复发(Recurrence);序列分析, DNA(Sequence Analysis, DNA);治疗失败(Treatment Failure)

DOI 10.1038/ncomms4469

PMID 24662245

发布时间 2022-04-10

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Nature communications

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Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia.

Nature communications

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Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia.

Nature communications

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Nature communications

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