换一批
换一批A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.
作者：
Parkinson Study Group QE3 Investigators [1]
;
M Flint,Beal [2]
;
David,Oakes [3]
;
Ira,Shoulson [1]
;
Claire,Henchcliffe [4]
;
Wendy R,Galpern [5]
;
Richard,Haas [6]
;
Jorge L,Juncos [7]
;
John G,Nutt [8]
;
Tiffini Smith,Voss [9]
;
Bernard,Ravina [10]
;
Clifford M,Shults [2]
;
Karen,Helles [2]
;
Victoria,Snively [11]
;
Mark F,Lew [2]
;
Brian,Griebner [12]
;
Arthur,Watts [2]
;
Shan,Gao [13]
;
Emmanuelle,Pourcher [13]
;
Louisette,Bond [14]
;
Katie,Kompoliti [15]
;
Pinky,Agarwal [15]
;
Cherissa,Sia [16]
;
Mandar,Jog [16]
;
Linda,Cole [16]
;
Munira,Sultana [17]
;
Roger,Kurlan [18]
;
Irene,Richard [18]
;
Cheryl,Deeley [19]
;
Cheryl H,Waters [19]
;
Angel,Figueroa [1]
;
Ani,Arkun [7]
;
Matthew,Brodsky [20]
;
William G,Ondo [21]
;
Christine B,Hunter [21]
;
Joohi,Jimenez-Shahed [21]
;
Alicia,Palao [22]
;
Janis M,Miyasaki [22]
;
Julie,So [23]
;
James,Tetrud [23]
;
Liza,Reys [23]
;
Katharine,Smith [24]
;
Carlos,Singer [24]
;
Anita,Blenke [25]
;
David S,Russell [25]
;
Candace,Cotto [26]
;
Joseph H,Friedman [27]
;
Margaret,Lannon [28]
;
Lin,Zhang [29]
;
Edward,Drasby [30]
;
Rajeev,Kumar [31]
;
Thyagarajan,Subramanian [31]
;
Donna Stuppy,Ford [32]
;
David A,Grimes [32]
;
Diane,Cote [32]
;
Jennifer,Conway [33]
;
Andrew D,Siderowf [34]
;
Marian Leslie,Evatt [6]
;
Barbara,Sommerfeld [35]
;
Abraham N,Lieberman [36]
;
Michael S,Okun [36]
;
Ramon L,Rodriguez [36]
;
Stacy,Merritt [36]
;
Camille Louise,Swartz [37]
;
W R Wayne,Martin [37]
;
Pamela,King [38]
;
Natividad,Stover [38]
;
Stephanie,Guthrie [38]
;
Ray L,Watts [39]
;
Anwar,Ahmed [39]
;
Hubert H,Fernandez [39]
;
Adrienna,Winters [40]
;
Zoltan,Mari [40]
;
Ted M,Dawson [40]
;
Becky,Dunlop [41]
;
Andrew S,Feigin [41]
;
Barbara,Shannon [42]
;
Melissa Jill,Nirenberg [1]
;
Mattson,Ogg [43]
;
Samuel A,Ellias [43]
;
Cathi-Ann,Thomas [44]
;
Karen,Frei [45]
;
Ivan,Bodis-Wollner [45]
;
Sofya,Glazman [45]
;
Thomas,Mayer [46]
;
Robert A,Hauser [47]
;
Rajesh,Pahwa [47]
;
April,Langhammer [48]
;
Ranjit,Ranawaya [48]
;
Lorelei,Derwent [49]
;
Kapil D,Sethi [49]
;
Buff,Farrow [49]
;
Rajan,Prakash [5]
;
Irene,Litvan [50]
;
Annette,Robinson [51]
;
Alok,Sahay [51]
;
Maureen,Gartner [52]
;
Vanessa K,Hinson [53]
;
Samuel,Markind [53]
;
Melisa,Pelikan [54]
;
Joel S,Perlmutter [54]
;
Johanna,Hartlein [55]
;
Eric,Molho [55]
;
Sharon,Evans [56]
;
Charles H,Adler [56]
;
Amy,Duffy [56]
;
Marlene,Lind [57]
;
Lawrence,Elmer [58]
;
Kathy,Davis [58]
;
Julia,Spears [58]
;
Stephanie,Wilson [59]
;
Maureen A,Leehey [60]
;
Neal,Hermanowicz [60]
;
Shari,Niswonger [61]
;
Holly A,Shill [61]
;
Sanja,Obradov [62]
;
Alex,Rajput [62]
;
Marilyn,Cowper [63]
;
Stephanie,Lessig [63]
;
David,Song [63]
;
Deborah,Fontaine [64]
;
Cindy,Zadikoff [64]
;
Karen,Williams [65]
;
Karen A,Blindauer [65]
;
Jo,Bergholte [65]
;
Clara Schindler,Propsom [66]
;
Mark A,Stacy [66]
;
Joanne,Field [67]
;
Dragos,Mihaila [67]
;
Mark,Chilton [68]
;
Ergun Y,Uc [68]
;
Jeri,Sieren [69]
;
David K,Simon [69]
;
Lauren,Kraics [69]
;
Althea,Silver [70]
;
James T,Boyd [70]
;
Robert W,Hamill [70]
;
Christopher,Ingvoldstad [70]
;
Jennifer,Young [71]
;
Karen,Thomas [71]
;
Sandra K,Kostyk [72]
;
Joanne,Wojcieszek [73]
;
Ronald F,Pfeiffer [74]
;
Michel,Panisset [74]
;
Monica,Beland [75]
;
Stephen G,Reich [75]
;
Michelle,Cines [75]
;
Nancy,Zappala [76]
;
Jean,Rivest [77]
;
Richard,Zweig [77]
;
L Pepper,Lumina [78]
;
Colette Lynn,Hilliard [40]
;
Stephen,Grill [79]
;
Marye,Kellermann [80]
;
Paul,Tuite [80]
;
Susan,Rolandelli [81]
;
Un Jung,Kang [81]
;
Joan,Young [82]
;
Jayaraman,Rao [82]
;
Maureen M,Cook [83]
;
Lawrence,Severt [83]
;
Karyn,Boyar
作者单位：
Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.
[1]
Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.
[2]
Department of Neurology, Georgetown University, Washington, DC.
[3]
National Institutes of Health, Bethesda, Maryland.
[4]
Department of Neurosciences, University of California, San Diego, La Jolla.
[5]
Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia.
[6]
Department of Neurology, Oregon Health and Science University, Portland.
[7]
Merck, New Jersey.
[8]
Biogen Idec, Cambridge, Massachusetts.
[9]
Department of Neurosciences, University of California, San Diego, La Jolla10VA Medical Center, San Diego, California.
[10]
Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles.
[11]
Department of Biostatistics, University of Rochester Medical Center, Rochester, New York12Department of Neurology, University of Rochester, Rochester, New York.
[12]
Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte-Anne, Québec, Canada.
[13]
Rush University Medical Center, Chicago, Illinois.
[14]
Booth Gardner Parkinson's Care Center, EvergreenHealth, Kirkland, Washington.
[15]
London Health Sciences Centre, London, Ontario, Canada.
[16]
Overlook Medical Center, Atlantic Neuroscience Institute, Summit, New Jersey.
[17]
Department of Neurology, University of Rochester, Rochester, New York.
[18]
Columbia University Medical Center, Neurological Institute, New York, New York.
[19]
Department of Neurology, University of Texas Health Science Center at Houston.
[20]
Department of Neurology, Baylor College of Medicine, Houston, Texas.
[21]
Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
[22]
The Parkinson's Institute and Clinical Center, Sunnyvale, California.
[23]
Department of Neurology, University of Miami School of Medicine, Miami, Florida.
[24]
Institute for Neurodegenerative Disorders, New Haven, Connecticut.
[25]
Department of Neurology, Butler Hospital, Providence, Rhode Island26Alpert Medical School, Brown University, Providence, Rhode Island.
[26]
Department of Neurology, Butler Hospital, Providence, Rhode Island27Port City Neurology, Inc, Scarborough, Maine.
[27]
Department of Neurology, University of California, Davis, School of Medicine and Sacramento VA Medical Center, Sacramento.
[28]
Port City Neurology, Inc, Scarborough, Maine.
[29]
Colorado Neurological Institute, Englewood.
[30]
Milton S. Hershey Medical Center, Department of Neurology, Pennsylvania State Hershey College of Medicine, Hershey.
[31]
Ottawa Hospital Civic Site, Ottawa, Ontario, Canada.
[32]
Avid Radiopharmaceuticals, Philadelphia, Pennsylvania.
[33]
Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia33Atlanta VA Medical Center, Atlanta, Georgia.
[34]
Muhammad Ali Parkinson Center, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona.
[35]
Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.
[36]
Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada.
[37]
Department of Neurology, University of Alabama at Birmingham.
[38]
Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio.
[39]
Department of Neurology, Johns Hopkins University, Baltimore, Maryland.
[40]
Feinstein Institute for Medical Research, Center for Neurosciences, Manhasset, New York.
[41]
Department of Neurology, New York University Langone Medical Center, New York.
[42]
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.
[43]
The Parkinson's and Movement Disorder Institute, Fountain Valley, California.
[44]
State University of New York, Downstate Medical Center, Brooklyn, New York.
[45]
Department of Neurology, University of South Florida, Tampa.
[46]
Department of Neurology, University of Kansas Medical Center, Kansas City.
[47]
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
[48]
Department of Neurology, Georgia Health Science University, Augusta.
[49]
Department of Neurology, University of Louisville, Kentucky.
[50]
University of Cincinnati College of Medicine, Cincinnati, Ohio.
[51]
Department of Neurology, Medical University of South Carolina, Charleston.
[52]
Associated Neurologists, PC, Danbury, Connecticut.
[53]
Department of Neurology, Washington University in St Louis, Missouri.
[54]
Movement Disorders Center, Albany Medical Center, Albany, New York.
[55]
Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona.
[56]
Center for Neurological Health, University of Toledo, Toledo, Ohio.
[57]
Department of Neurology, Medical University of Ohio at Toledo.
[58]
Department of Neurology, University of Colorado Health Science Center, Denver.
[59]
Department of Neurology, University of California, Irvine Medical Center, Irvine.
[60]
Banner Sun Health Research Institute, Sun City, Arizona.
[61]
Department of Neurology, University of Saskatchewan, Royal University Hospital, Saskatchewan, Canada.
[62]
Department of Neurology, University of California, San Diego, La Jolla.
[63]
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
[64]
Department of Neurology, Medical College of Wisconsin, Milwaukee.
[65]
Department of Neurology, Duke University, Durham, North Carolina.
[66]
State University of New York Upstate Medical Center and Syracuse VA Medical Center, Syracuse.
[67]
Department of Neurology, University of Iowa, Iowa City.
[68]
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
[69]
Department of Neurology, University of Vermont College of Medicine, Burlington.
[70]
Department of Neurology, Ohio State University, Columbus.
[71]
Department of Neurology, Indiana University School of Medicine, Indianapolis.
[72]
Department of Neurology, University of Tennessee Health Science Center, Memphis.
[73]
Department of Neurology, CHUM-Hôpital Notre-Dame, Montréal, Québec, Canada.
[74]
Department of Neurology, University of Maryland School of Science, Baltimore.
[75]
Department of Neurology, University of Sherbrooke, Québec, Canada.
[76]
Department of Neurology, Louisiana State University Health Science Center, Shreveport.
[77]
Lewis Hall Singletary Oncology Center, Thomasville, Georgia.
[78]
Parkinson and Movement Disorders Center of Maryland, Elkridge.
[79]
Department of Neurology, University of Minnesota, Minneapolis.
[80]
Department of Neurology, University of Chicago, Chicago, Illinois.
[81]
Department of Neurology, Ochsner Clinic Foundation, New Orleans, Louisiana.
[82]
Department of Neurology, Beth Israel Medical Center, New York, New York.
[83]
主题词
老年人(Aged);抗氧化剂(Antioxidants);剂量效应关系, 药物(Dose-Response Relationship, Drug);双盲法(Double-Blind Method);早期诊断(Early Diagnosis);女(雌)性(Female);人类(Humans);男(雄)性(Male);中年人(Middle Aged);帕金森病(Parkinson Disease);前瞻性研究(Prospective Studies);治疗结果(Treatment Outcome);泛醌(Ubiquinone)
DOI
10.1001/jamaneurol.2014.131
PMID
24664227
发布时间
2022-04-08
- 浏览21
JAMA neurology
JAMA neurology
2014年71卷5期
543-52页
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