Disseminated arterial calcification and enhanced myogenic response are associated with abcc6 deficiency in a mouse model of pseudoxanthoma elasticum.
第一作者:
Gilles,Kauffenstein
第一单位:
From the CNRS UMR 6214, INSERM U1083, l'UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l'UNAM, Université d'Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Université de Lorraine, Vandoeuvre-lès-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands (T.G.G., A.A.B.); and Departments of Ophthalmology (A.A.B.) and Clinical Genetics (A.A.B.), Academic Medical Center, Amsterdam, The Netherlands.
作者:
主题词
ATP结合匣式转运子(ATP-Binding Cassette Transporters);动物(Animals);动脉(Arteries);钙(Calcium);细胞转分化(Cell Transdifferentiation);软骨发生(Chondrogenesis);胶原Ⅱ型(Collagen Type II);核心结合因子α1亚基(Core Binding Factor Alpha 1 Subunit);疾病模型, 动物(Disease Models, Animal);弹性组织(Elastic Tissue);基因表达调控(Gene Expression Regulation);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);多药耐药相关蛋白质类(Multidrug Resistance-Associated Proteins);骨生成(Osteogenesis);骨桥蛋白质(Osteopontin);弹性假黄瘤(Pseudoxanthoma Elasticum);RNA, 信使(RNA, Messenger);局部血流(Regional Blood Flow);SOXB1转录因子类(SOXB1 Transcription Factors);血管收缩(Vasoconstriction)
DOI
10.1161/ATVBAHA.113.302943
PMID
24675664
发布时间
2021-10-21
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