Brinzolamide nanocrystal formulations for ophthalmic delivery: reduction of elevated intraocular pressure in vivo.-论文-万方医学网

作者： Annika,Tuomela ^[1] ; Peng,Liu ^[2] ; Jooseppi,Puranen ^[3] ; Seppo,Rönkkö ^[4] ; Timo,Laaksonen ^[2] ; Giedrius,Kalesnykas ^[5] ; Olli,Oksala ^[6] ; Jukka,Ilkka ^[7] ; Johanna,Laru ^[8] ; Kristiina,Järvinen ^[4] ; Jouni,Hirvonen ^[2] ; Leena,Peltonen ^[2]

作者单位： Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland. Electronic address: annika.tuomela@helsinki.fi. ^[1] Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland. ^[2] Department of Ophthalmology, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. ^[3] School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. ^[4] Department of Ophthalmology, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland; Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland. ^[5] Santen Oy, Tampere, Finland. ^[6] Oy Medfiles Ltd., Kuopio, Finland. ^[7] Orion Pharma R&D, Formulation Research, Espoo, Finland. ^[8]

主题词动物(Animals);量热法, 差式扫描(Calorimetry, Differential Scanning);碳酸酐酶抑制剂(Carbonic Anhydrase Inhibitors);细胞系(Cell Line);细胞存活(Cell Survival);化学, 药物(Chemistry, Pharmaceutical);疾病模型, 动物(Disease Models, Animal);上皮, 角膜(Epithelium, Corneal);辅药(Excipients);青光眼(Glaucoma);人类(Humans);眼内压(Intraocular Pressure);男(雄)性(Male);显微镜检查, 电子, 扫描(Microscopy, Electron, Scanning);纳米粒子(Nanoparticles);纳米技术(Nanotechnology);粒子大小(Particle Size);聚山梨醇酯类(Polysorbates);大鼠, Wistar(Rats, Wistar);溶解度(Solubility);磺胺类(Sulfonamides);表面特性(Surface Properties);工艺学, 制药(Technology, Pharmaceutical);噻嗪类(Thiazines);时间因素(Time Factors)

DOI 10.1016/j.ijpharm.2014.03.048

PMID 24680962

发布时间 2022-03-30

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Brinzolamide nanocrystal formulations for ophthalmic delivery: reduction of elevated intraocular pressure in vivo.

International journal of pharmaceutics

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International journal of pharmaceutics

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Brinzolamide nanocrystal formulations for ophthalmic delivery: reduction of elevated intraocular pressure in vivo.

International journal of pharmaceutics

相似文献

International journal of pharmaceutics

相关期刊

检索历史清除