Src is required for mechanical stretch-induced cardiomyocyte hypertrophy through angiotensin II type 1 receptor-dependent β-arrestin2 pathways.
作者:
主题词
血管紧张素原(Angiotensinogen);动物(Animals);动物, 新生(Animals, Newborn);抑制蛋白类(Arrestins);印迹法, 蛋白质(Blotting, Western);心脏扩大(Cardiomegaly);细胞, 培养的(Cells, Cultured);超声心动描记术(Echocardiography);免疫酶技术(Immunoenzyme Techniques);免疫沉淀法(Immunoprecipitation);肌醇1,4,5-三磷酸(Inositol 1,4,5-Trisphosphate);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);丝裂原活化蛋白激酶1(Mitogen-Activated Protein Kinase 1);丝裂原活化蛋白激酶3(Mitogen-Activated Protein Kinase 3);肌细胞, 心脏(Myocytes, Cardiac);磷酰化(Phosphorylation);RNA, 信使(RNA, Messenger);大鼠(Rats);受体, 血管紧张素, 1型(Receptor, Angiotensin, Type 1);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);信号传导(Signal Transduction);应力, 物理(Stress, Mechanical);src族激酶类(src-Family Kinases)
DOI
10.1371/journal.pone.0092926
PMID
24699426
发布时间
2021-10-21
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