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首页> Journal of immunological methods> Characterization of in vitro antibody-dependent cell-mediated cytotoxicity activity of therapeutic antibodies - impact of effector cells.

Characterization of in vitro antibody-dependent cell-mediated cytotoxicity activity of therapeutic antibodies - impact of effector cells.

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第一作者： Shan,Chung

第一单位： Department of Bioanalytical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, United States. Electronic address: chung.shan@gene.com.

作者： Shan,Chung ^[1] ; Yuwen L,Lin ^[2] ; Chae,Reed ^[2] ; Carl,Ng ^[2] ; Zhijie Jey,Cheng ^[3] ; Fabio,Malavasi ^[4] ; Jihong,Yang ^[2] ; Valerie,Quarmby ^[2] ; An,Song ^[2]

作者单位： Department of Bioanalytical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, United States. Electronic address: chung.shan@gene.com. ^[1] Department of Bioanalytical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, United States. ^[2] Promega Corporation, Madison, WI 53711, United States. Electronic address: jey.cheng@promega.com. ^[3] Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Torino, Italy. Electronic address: fabio.malavasi@unito.it. ^[4]

关键词 ADCC assay Afucosylated antibody Antibody-dependent cell-mediated cytotoxicity CD16a Glycosylation Monoclonal antibody

主题词抗体依赖细胞细胞毒性(Antibody-Dependent Cell Cytotoxicity);细胞系(Cell Line);细胞毒性试验, 免疫(Cytotoxicity Tests, Immunologic);糖基化(Glycosylation);人类(Humans);免疫球蛋白同种异型(Immunoglobulin Allotypes);免疫球蛋白G(Immunoglobulin G);免疫疗法, 过继(Immunotherapy, Adoptive);杀伤细胞, 天然(Killer Cells, Natural);白细胞, 单核(Leukocytes, Mononuclear);受体, IgG(Receptors, IgG);结果可重复性(Reproducibility of Results);转基因(Transgenes)

DOI 10.1016/j.jim.2014.03.021

PMID 24704820

发布时间 2014-05-27

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Journal of immunological methods

63-75页

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