Synergistic and antagonistic drug combinations depend on network topology.

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作者： Ning,Yin ^[1] ; Wenzhe,Ma ^[2] ; Jianfeng,Pei ^[1] ; Qi,Ouyang ^[3] ; Chao,Tang ^[3] ; Luhua,Lai ^[4]

作者单位： Center for Quantitative Biology, Peking University, Beijing, China. ^[1] Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America. ^[2] Center for Quantitative Biology, Peking University, Beijing, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China; School of Physics, Peking University, Beijing, China. ^[3] Center for Quantitative Biology, Peking University, Beijing, China; BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. ^[4]

主题词复方合剂(Drug Combinations);药物设计(Drug Design);药物相互作用(Drug Interactions);药物协同作用(Drug Synergism);模型, 理论(Models, Theoretical)

DOI 10.1371/journal.pone.0093960

PMID 24713621

发布时间 2021-10-21

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