VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats.-论文-万方医学网

作者： Abhijit M,Godbole ^[1] ; Senthilmurugan,Ramalingam ^[1] ; Vidya P,Ramamurthy ^[1] ; Aakanksha,Khandelwal ^[2] ; Robert D,Bruno ^[2] ; Vijay V,Upreti ^[3] ; Lalji K,Gediya ^[1] ; Puranik,Purushottamachar ^[1] ; Hannah W,Mbatia ^[1] ; Sankar,Addya ^[4] ; Nicholas,Ambulos ^[5] ; Vincent C O,Njar ^[6]

作者单位： Department of Pharmacology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201-1559, USA; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201-1559, USA. ^[1] Department of Pharmacology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201-1559, USA. ^[2] Department of Pharmaceutical sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA. ^[3] Department of Cancer Biology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, PA 19107, USA. ^[4] Genomic Core Facility, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201-1559, USA. ^[5] Department of Pharmacology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201-1559, USA; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201-1559, USA; Marlene Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201-1559, USA. Electronic address: vnjar@som.umaryland.edu. ^[6]

主题词投药, 口服(Administration, Oral);动物(Animals);抗肿瘤药(Antineoplastic Agents);自噬(Autophagy);生物利用度(Biological Availability);乳腺肿瘤(Breast Neoplasms);细胞周期(Cell Cycle);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);减量调节(Down-Regulation);药物协同作用(Drug Synergism);女(雌)性(Female);人类(Humans);咪唑类(Imidazoles);细胞内间隙(Intracellular Space);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);毒胡萝卜内酯(Thapsigargin);维甲酸(Tretinoin);增量调节(Up-Regulation);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1016/j.ejphar.2014.04.004

PMID 24726842

发布时间 2021-10-21

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VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats.

European journal of pharmacology

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European journal of pharmacology

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VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats.

European journal of pharmacology

相似文献

European journal of pharmacology

相关期刊

检索历史清除