The effect of everolimus on renal angiomyolipoma in patients with tuberous sclerosis complex being treated for subependymal giant cell astrocytoma: subgroup results from the randomized, placebo-controlled, Phase 3 trial EXIST-1.

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作者： J Chris,Kingswood ^[1] ; Sergiusz,Jozwiak ^[2] ; Elena D,Belousova ^[3] ; Michael D,Frost ^[4] ; Rachel A,Kuperman ^[5] ; E Martina,Bebin ^[6] ; Bruce R,Korf ^[7] ; J Robert,Flamini ^[8] ; Michael H,Kohrman ^[9] ; Steven P,Sparagana ^[10] ; Joyce Y,Wu ^[11] ; Thomas,Brechenmacher ^[12] ; Karen,Stein ^[13] ; Noah,Berkowitz ^[13] ; John J,Bissler ^[14] ; David N,Franz ^[15]

作者单位： Sussex Renal Unit, Royal Sussex County Hospital, Brighton, UK The Trafford Department of Renal Medicine, Royal Sussex County Hospital, Brighton BN2 5BE, UK. ^[1] Department of Child Neurology, The Children's Memorial Health Institute, Warsaw, Poland. ^[2] Moscow Research Institute of Pediatrics and Pediatric Surgery, Moscow, Russia. ^[3] Minnesota Epilepsy Group, St. Paul, MN, USA. ^[4] Department of Neurology, Children's Hospital & Research Center Oakland, Oakland, CA, USA. ^[5] Department of Neurology, University of Alabama School of Medicine, Birmingham, AL, USA. ^[6] Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA. ^[7] Children's Healthcare of Atlanta, Atlanta, GA, USA. ^[8] University of Chicago Medicine Comer Children's Hospital, Chicago, IL, USA. ^[9] Texas Scottish Rite Hospital for Children, Dallas, TX, USA. ^[10] Division of Pediatric Neurology, Mattel Children's Hospital UCLA, Los Angeles, CA, USA. ^[11] Novartis Pharmaceuticals S.A.S., Rueil-Malmaison, France. ^[12] Novartis Pharmaceuticals Corporation, Florham Park, NJ, USA. ^[13] Present address: Division of Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA Present address: Division of Nephrology, Le Bonheur Children's Hospital and University of Tennessee College of Medicine, Memphis, TN, USA. ^[14] Department of Pediatrics and Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. ^[15]

关键词 everolimus renal angiomyolipoma tuberous sclerosis complex