Engineering theranostic nanovehicles capable of targeting cerebrovascular amyloid deposits.

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第一作者： Edward K,Agyare

第一单位： Division of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, 1520 S. MLK BLVD, Tallahassee 32307, USA.

作者： Edward K,Agyare ^[1] ; Kristen M,Jaruszewski ^[2] ; Geoffry L,Curran ^[3] ; Jens T,Rosenberg ^[4] ; Samuel C,Grant ^[5] ; Val J,Lowe ^[6] ; Subramanian,Ramakrishnan ^[7] ; Anant K,Paravastu ^[5] ; Joseph F,Poduslo ^[3] ; Karunya K,Kandimalla ^[8]

作者单位： Division of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, 1520 S. MLK BLVD, Tallahassee 32307, USA. ^[1] Department of Pharmaceutics and Brain Barriers Research Center, University of Minnesota, 308 Harvard St. SE, Room 9-149A WDH, Minneapolis 55455, USA; Molecular Neurobiology Laboratory, Departments of Neurology, Neuroscience, and Biochemistry/Molecular Biology, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester 55905, USA. ^[2] Molecular Neurobiology Laboratory, Departments of Neurology, Neuroscience, and Biochemistry/Molecular Biology, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester 55905, USA. ^[3] The Florida State University and National High Magnetic Field Laboratory, 1800 East Paul Dirac Drive, Tallahassee 32310, USA. ^[4] The Florida State University and National High Magnetic Field Laboratory, 1800 East Paul Dirac Drive, Tallahassee 32310, USA; Department of Chemical and Biomedical Engineering, Florida A&M University-Florida State University College of Engineering, 2525 Pottsdamer Street, Tallahassee 32310, USA. ^[5] Nuclear Medicine, Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester 55905, USA. ^[6] Department of Chemical and Biomedical Engineering, Florida A&M University-Florida State University College of Engineering, 2525 Pottsdamer Street, Tallahassee 32310, USA. ^[7] Department of Pharmaceutics and Brain Barriers Research Center, University of Minnesota, 308 Harvard St. SE, Room 9-149A WDH, Minneapolis 55455, USA; Molecular Neurobiology Laboratory, Departments of Neurology, Neuroscience, and Biochemistry/Molecular Biology, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester 55905, USA. Electronic address: kkandima@umn.edu. ^[8]

关键词 Alzheimer's disease Amyloid beta protein Blood brain barrier Cerebrovascular amyloid angiopathy Cerebrovascular inflammation Theranostic nanoparticles