Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy.-论文-万方医学网

作者： Constanza J,Cortes ^[1] ; Shuo-Chien,Ling ^[2] ; Ling T,Guo ^[3] ; Gene,Hung ^[4] ; Taiji,Tsunemi ^[1] ; Linda,Ly ^[1] ; Seiya,Tokunaga ^[2] ; Edith,Lopez ^[1] ; Bryce L,Sopher ^[5] ; C Frank,Bennett ^[4] ; G Diane,Shelton ^[3] ; Don W,Cleveland ^[6] ; Albert R,La Spada ^[7]

作者单位： Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA. ^[1] Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA. ^[2] Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA. ^[3] Isis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA. ^[4] Department of Neurology, University of Washington, Seattle, WA 98195, USA. ^[5] Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA. ^[6] Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Rady Children's Hospital, San Diego, CA 92123, USA. Electronic address: alaspada@ucsd.edu. ^[7]

主题词肌动蛋白类(Actins);年龄因素(Age Factors);动物(Animals);体重(Body Weight);脑(Brain);疾病模型, 动物(Disease Models, Animal);疾病恶化(Disease Progression);基因表达调控(Gene Expression Regulation);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);运动神经元(Motor Neurons);动作障碍(Movement Disorders);肌力(Muscle Strength);肌, 骨骼(Muscle, Skeletal);肌疾病, 萎缩性(Muscular Disorders, Atrophic);肽类(Peptides);表型(Phenotype);受体, 雄激素(Receptors, Androgen)

DOI 10.1016/j.neuron.2014.03.001

PMID 24742458

发布时间 2021-10-21

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Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy.

Neuron

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Neuron

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Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy.

Neuron

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Neuron

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