Base substituted 5'-O-(N-isoleucyl)sulfamoyl nucleoside analogues as potential antibacterial agents.

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第一作者： Bharat,Gadakh

第一单位： KU Leuven, Medicinal Chemistry, Rega Institute for Medical Research, Leuven, Belgium.

作者： Bharat,Gadakh ^[1] ; Gaston,Vondenhoff ^[1] ; Eveline,Lescrinier ^[1] ; Jef,Rozenski ^[1] ; Mathy,Froeyen ^[1] ; Arthur,Van Aerschot ^[2]

作者单位： KU Leuven, Medicinal Chemistry, Rega Institute for Medical Research, Leuven, Belgium. ^[1] KU Leuven, Medicinal Chemistry, Rega Institute for Medical Research, Leuven, Belgium. Electronic address: Arthur.VanAerschot@REGA.KULeuven.be. ^[2]

关键词 Aminoacyl-tRNA synthetases Base modifications Enzyme inhibitors In vitro affinity Molecular modeling Nucleoside antibiotics

主题词腺苷(Adenosine);抗菌药(Anti-Bacterial Agents);剂量效应关系, 药物(Dose-Response Relationship, Drug);大肠杆菌(Escherichia coli);微生物敏感性试验(Microbial Sensitivity Tests);分子构象(Molecular Conformation);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmc.2014.03.040

PMID 24746466

发布时间 2014-04-28

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