Ketamine exposure in early development impairs specification of the primary germ cell layers.

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作者： Oluwaseun,Akeju ^[1] ; Brandi N,Davis-Dusenbery ^[2] ; Seth H,Cassel ^[2] ; Justin K,Ichida ^[2] ; Kevin,Eggan ^[2]

作者单位： Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; The Howard Hughes Medical Institute, Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: oluwaseun.akeju@mgh.harvard.edu. ^[1] The Howard Hughes Medical Institute, Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. ^[2]

关键词 Differentiation Ketamine Mesoendoderm Mouse embryonic stem cells NMDA Neurogenesis

主题词动物(Animals);细胞分化(Cell Differentiation);发育障碍(Developmental Disabilities);地卓西平马来酸盐(Dizocilpine Maleate);剂量效应关系, 药物(Dose-Response Relationship, Drug);胚胎, 哺乳动物(Embryo, Mammalian);拟胚体(Embryoid Bodies);胚胎发育(Embryonic Development);兴奋性氨基酸拮抗剂(Excitatory Amino Acid Antagonists);女(雌)性(Female);流式细胞术(Flow Cytometry);氯胺酮(Ketamine);男(雄)性(Male);小鼠(Mice);微阵列分析(Microarray Analysis);运动神经元(Motor Neurons);神经组织蛋白质类(Nerve Tissue Proteins);妊娠(Pregnancy);产前暴露迟发效应(Prenatal Exposure Delayed Effects)

DOI 10.1016/j.ntt.2014.04.001

PMID 24746641

发布时间 2021-10-21

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Neurotoxicology and teratology

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Ketamine exposure in early development impairs specification of the primary germ cell layers.

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Ketamine exposure in early development impairs specification of the primary germ cell layers.

Neurotoxicology and teratology

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Neurotoxicology and teratology

相关期刊

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