换一批Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor.
第一作者：
Ryan C,Tsou
第一单位：
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
作者：
关键词
BAT, Brown adipose tissueCNTF, Ciliary neurotrophic factorCre, Cre recombinaseGTT, Glucose tolerance testHFD, High-fat dietHPA, hypothalamus–pituitary–adrenalHypothalamusIL-6, Interleukin-6ITT, Insulin tolerance testJAK2, Janus kinase 2LepRb, Leptin receptor long formLeptinNkx2.1, NK2 homeobox 1 protein or thyroid transcription factor-1ObesityPI3K, Phosphatidylinositol 3-kinasePOMC, ProopiomelanocortinPTP1B, Protein tyrosine phosphatase 1BPTPs, Protein tyrosine phosphatasesPhosphatasePrdm16, PR domain containing 16SHP2, Src homology 2 domain-containing protein tyrosine phosphataseSTAT3, Signal transducer and activator of transcription 3UCP1, Uncoupling protein 1WAT, White adipose tissuedb/db, Leptin receptor-deficient miceob/ob, leptin-deficient mice
DOI
10.1016/j.molmet.2014.01.008
PMID
24749060
发布时间
2021-10-21
- 浏览110
Molecular metabolism
2014年3卷3期
301-12页
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