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Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

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第一作者： Lisa,Fredriksson

第一单位： Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands.

作者： Lisa,Fredriksson ^[1] ; Steven,Wink ^[1] ; Bram,Herpers ^[1] ; Giulia,Benedetti ^[1] ; Mackenzie,Hadi ^[2] ; Hans,de Bont ^[1] ; Geny,Groothuis ^[2] ; Mirjam,Luijten ^[3] ; Erik,Danen ^[1] ; Marjo,de Graauw ^[1] ; John,Meerman ^[1] ; Bob,van de Water ^[4]

作者单位： Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands. ^[1] Division of Pharmacokinetics, Toxicology and Targeting, Department of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands. ^[2] The National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands. ^[3] Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands b.water@lacdr.leidenuniv.nl. ^[4]

关键词 RNA interference drug-induced liver injury high content microscopy transcriptomics