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Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (-)-[(18)F]Flubatine in humans.

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第一作者： Marianne,Patt

第一单位： Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, D-04103 Leipzig, Germany. Electronic address: marianne.patt@uniklinik-leipzig.de.

作者： Marianne,Patt ^[1] ; Georg A,Becker ^[2] ; Udo,Grossmann ^[2] ; Bernd,Habermann ^[2] ; Andreas,Schildan ^[2] ; Stephan,Wilke ^[2] ; Winnie,Deuther-Conrad ^[3] ; Susanne,Graef ^[4] ; Steffen,Fischer ^[3] ; René,Smits ^[5] ; Alexander,Hoepping ^[5] ; Gudrun,Wagenknecht ^[6] ; Jörg,Steinbach ^[3] ; Hermann-Josef,Gertz ^[4] ; Swen,Hesse ^[7] ; Peter,Schönknecht ^[4] ; Peter,Brust ^[3] ; Osama,Sabri ^[7]

作者单位： Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, D-04103 Leipzig, Germany. Electronic address: marianne.patt@uniklinik-leipzig.de. ^[1] Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, D-04103 Leipzig, Germany. ^[2] Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Permoserstrasse 15, D-04318 Leipzig, Germany. ^[3] Department of Psychiatry, University of Leipzig, Semmelweisstrasse 10, D-04103 Leipzig, Germany. ^[4] ABX advanced biochemical compounds GmbH, Heinrich-Glaeser-Strasse 10-14, D-01454 Radeberg, Germany. ^[5] Multimodal Image Processing, Central Institute ZEA-2-Electronic Systems, Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany. ^[6] Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, D-04103 Leipzig, Germany; Integrated Research and Treatment Centre (IFB) Adiposity Diseases, Leipzig University Medical Centre, Leipzig, Germany. ^[7]

关键词 Clinical trial Flubatine Fluorine-18 Metabolism PET Plasma protein binding

主题词苯甲酰胺类(Benzamides);血蛋白质类(Blood Proteins);人类(Humans);动力学(Kinetics);蛋白质结合(Protein Binding);放射性示踪剂(Radioactive Tracers)

DOI 10.1016/j.nucmedbio.2014.03.018

PMID 24768146

发布时间 2016-11-25

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